Novak Djokovic described the grueling five-set, nearly five‑hour marathon that ended his US Open campaign as something he "despised". The loss has reignited the debate about whether the Serbian legend should hang up his racket and end a career that has been studded with an unprecedented collection of titles. For the first time in his storied Grand Slam history, the 24‑time major champion was eliminated in the opening round of the US Open.

Argentine youngster Mariano Navone produced the upset, handing Djokovic a defeat that broke a perfect 19‑0 record for the Serbian in first‑round matches at Flushing Meadows. The loss also marked the first time Djokovic has failed to win his opening match at a major since Paul Goldstein knocked him out in the first round of the Australian Open back in 2006. The match itself was a physical spectacle.

Djokovic, now 39, appeared visibly exhausted, doubled over in pain on several occasions, and suffered bouts of nausea that forced him to vomit on court. At one point he fought back tears, yet managed a courteous smile as he congratulated Navone, who was ranked world No. 49, on what will likely be the biggest victory of his career. In recent weeks Djokovic has been candid about a serious underlying health issue that he first disclosed two weeks ago.

While he remains determined to address the problem, the symptoms have taken a toll: frequent sickness, severe fatigue, and a general sense of physical depletion. These concerns have prompted former champions and fellow players to weigh in on his future. Former Wimbledon champion Marion Bartoli described watching Djokovic struggle as "heart‑breaking" and emphasized that his health should be the top priority.

"The way he was physically suffering is worrying. He needs proper medical checks to determine what’s happening," she said. British former world No. 1 Tim Henman, who also faced Djokovic in a US Open semi‑final in his playing days, acknowledged that the match was a difficult spectacle but stopped short of calling for retirement.

"Djokovic wasn't feeling well on court, but he gave everything he could. When he was up two sets to one with a break in the fourth, you thought he could pull it off," Henman recalled. He added, "He was vomiting and lacked energy, while Navone, with his youth, seized the momentum in the final two sets." Henman was clear that retirement is a personal decision.

"Absolutely not – it’s his prerogative. He’s still ranked No.

5 in the world. If every athlete at that level retired early, the sport would suffer.

He should play as long as he feels able, and I don’t think he should quit now," he asserted. He also noted that while Djokovic’s competitive drive remains intact, the physical realities of a 39‑year‑old body battling illness cannot be ignored. "His mentality is still there, but the physical challenges are real," Henman said.

American player Ryan Harrison echoed the sentiment that Djokovic is battling his body. Harrison pointed out that the Serbian has also suffered a first‑round loss at the Cincinnati Open earlier in the month, adding to a recent run of disappointing results. "It’s frustrating when you’re fighting your body and can’t enjoy the moment. That’s a different kind of pain," Harrison explained.

He remains optimistic about Djokovic’s future, noting that the champion is likely aiming for a comeback in 2027 and still possesses the skill set to compete at the highest level. Djokovic has previously hinted that his ultimate retirement could come at the 2028 Los Angeles Olympics, where he hopes to represent Serbia one last time under his national flag. Whether that timeline holds true now is uncertain, given the seriousness of his health concerns and the physical strain evident in his recent performances. The broader tennis community is watching closely.

Fans can follow the ongoing US Open action on Sky Sports, with live streaming available through NOW and the Sky Sports app. The tournament continues to showcase high‑stakes matches, and the narrative surrounding Djokovic’s potential retirement adds an extra layer of intrigue to the event. In summary, Novak Djokovic’s recent US Open defeat has sparked a renewed conversation about the longevity of his career.

While his mental fortitude and competitive spirit appear undiminished, his physical condition raises legitimate questions about how much longer he can perform at the elite level. Former champions like Bartoli and Henman, as well as peers such as Harrison, stress the importance of health and caution against a hasty retirement decision. The Serbian star has hinted at an Olympic farewell in 2028, but the timeline may shift if his medical issues persist.

For now, the tennis world remains hopeful that Djokovic will recover, address his health challenges, and possibly return to the court stronger in the years ahead.